Physical dependence is an anticipated physiologic response to chronic therapy with drugs in this group, particularly the strong agonists. Physical dependence is revealed on abrupt discontinuance as an abstinence syndrome, which includes rhinorrhea, lacrimation, chills, gooseflesh, muscle aches, diarrhea, yawning, anxiety, and hostility. A more intense state of precipitated withdrawal results when an opioid antagonist is administered to a physically dependent individual.