Epilepsy drugs in pregnancy

Divalproex and barbiturates should be avoided. Those women already on divalproex and barbiturates should be switched to other drugs before pregnancy when possible. When seizures are controlled, maintenance medication may be reduced, if possible, to the lowest dose that provides control. If seizures are not controlled, medications and dosages will need to be adjusted prior to pregnancy, if possible. The frequency and severity of seizures may change during pregnancy. Regular monitoring by both an obstetrician and a neurologist is important. All women with epilepsy should be encouraged to register with the AED (Antiepileptic Drug) Pregnancy Registry.