Phenytoin adverse effects

Depression of the CNS occurs particularly in the cerebellum and vestibular system, causing nystagmus and ataxia. The elderly are highly susceptible to this effect. Gingival hyperplasia may cause the gums to grow over the teeth. Long-term use may lead to development of peripheral neuropathies and osteoporosis. Although phenytoin is the drug used most commonly worldwide for epilepsy due to its low cost per tablet, the cost of therapy may be much higher when the potential for serious toxicity and adverse eff ects is weighed.