Pregunta:
I. Oxcarbazepine
Autor: SuzukiRespuesta:
Oxcarbazepine is a prodrug that is rapidly reduced to the 10-monohydroxy (MHD) metabolite responsible for its anticonvulsant activity. MHD blocks sodium channels, preventing the spread of the abnormal discharge. It is also thought to modulate calcium channels. It is approved for use in adults and children with partial onset seizures. Oxcarbazepine is a less potent inducer of CYP3A4 and UGT than carbamazepine.
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