Extrapyrimidal toxicity treated by

This toxicity may be reversed by a decrease in dose and may be antagonized by concomitant use of muscarinic blocking agents. extrapyramidal effects are minimized by administration of an anticholinergic drug, such as benztropine. The therapeutic trade-off will be fewer EPS in exchange for the side effect of muscarinic-receptor blockade. [Note: Sometimes,the parkinsonian symptoms and akathisias persist despite the use of anticholinergic drugs.] Akathisia may respond better to β blockers or benzodiazepines rather than anticholinergic medications.