Formulations

Fluphenazine decanoate, haloperidol decanoate, risperidone microspheres, paliperidone palmitate, and olanzapine pamoate are long-acting injectable (LAI) formulations of antipsychotics that are administered via deep gluteal intramuscular injection or deltoid injection. These formulations have a therapeutic duration of action of up to 2 to 4 weeks and, therefore, are often used to treat outpatients and individuals who are noncompliant with oral medications.However, patients may still develop EPS, but the risk of EPS is lower with these LAI formulations compared to their respective oral formulations.