The dependence of pramipexole on renal function

The dependence of pramipexole on renal function for its elimination cannot be overly stressed. For example, cimetidine, which inhibits renal tubular secretion of organic bases, increases the half-life of pramipexole by 40 percent. The fluoroquinolone antibiotics and other inhibitors of the CYP1A2 hepatic enzyme have been shown to inhibit the metabolism of ropinirole and to enhance the AUC (area under the concentration vs. time) curve by some 80 percent. Rotigotine is a dopamine agonist used in the treatment of the signs and symptoms of early stage Parkinson disease. It is administered as a once-daily transdermal patch that provides even pharmacokinetics over 24 hours.