Pregunta:
Resistance to Anticancer Drugs by decreased activation of profrug
Autor: SuzukiRespuesta:
Resistance to the purine antimetabolites (mercaptopurine, thioguanine) and the pyrimidine antimetabolites (cytarabine, fluorouracil) can result from a decrease in the activity of the tumor cell enzymes needed to convert these prodrugs to their cytotoxic metabolites.
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