Pregunta:
Cytarabine (ARA-C) resistance
Autor: SuzukiRespuesta:
Resistance to ara-C may result from a defect in the transport process, a change in phosphorylating enzymes activity (especially deoxycytidine kinase), or an increased pool of the natural dCTP nucleotide. Increased deamination of the drug to uracil arabinoside(ara-U) can also cause resistance.
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