Clinical use fluorouracil

Fluorouracil is used in bladder, breast, colon, anal, head and neck, liver, and ovarian cancers. The drug can be used topically for keratoses and superficial basal cell carcinoma. 5-FU is employed primarily in the treatment of slowly growing solid tumors (for example, colorectal, breast, ovarian, pancreatic, and gastric carcinomas). When applied topically, 5-FU is also effective for the treatment of superficial basal cell carcinomas. 5-FU per se is devoid of antineoplastic activity.