Antifols: Pyrimethamine and Sulfonamides toxicity

High doses of pyrimethamine plus sulfadiazine are associated with gastric irritation, glossitis, neurologic symptoms (headache, insomnia, tremors, seizures), and hematotoxicity (megaloblastic anemia, thrombocytopenia). Antibiotic-associated colitis may occur during treatment with clindamycin.