Benznidazole

Benznidazole is a nitroimidazole derivative that inhibits protein and RNA synthesis in T. cruzi cells. It is an alternative choice for treatment of acute and indeterminate phases of Chagas disease, but therapy with benznidazole does not off er any signifi cant efficacy or toxicity advantages over that with nifurtimox. However, benznidazole is recommended as prophylaxis for preventing infections caused by T. cruzi among hematopoietic stem cell transplant recipients because treatment in potential donors is not always effective