Atovaquone

This quinine derivative, a component of Malarone (with proguanil), appears to disrupt mitochondrial electron transport in protozoa. Malarone is effective for both chemoprophylaxis (taken daily) and treatment of falciparum malaria. Abdominal pain and gastrointestinal effects occur at the higher doses needed for treatment. Atovaquone is an alternative treatment for P jiroveci infection.