Primaquine moa

Primaquine forms quinoline-quinone metabolites, which are electron-transferring redox compounds that act as cellular oxidants. The drug is a tissue schizonticide and also limits malaria transmission by acting as a gametocide. which may remain in the liver in the exoerythrocytic form after the erythrocytic form of the disease is eliminated.] The sexual (gametocytic) forms of all four plasmodia are destroyed in the plasma or are prevented from maturing later in the mosquito, thereby interrupting transmission of the disease. [Note: Primaquine is not eff ective against the erythrocytic stage of malaria and, therefore, is often used in conjunction with a blood schizonticide, such as chloroquine, quinine, mefl oquine, or pyrimethamine.]