Artmemesins pharmacokinetics and adverse effects

Oral, rectal, and intravenous (IV) preparations are available, but the short half-lives preclude their use in chemoprophylaxis. They are metabolized in the liver and are excreted primarily in bile. nausea vomiting diarrhoea. Extremely high doses may cause neurotoxicity and prolongation of the QT interval. These drugs are not used alone for chemoprophylaxis because of their short half-lives of 1–3 h.