Delavirdine

Delavirdine is not recommended in us it is rapidly absorbed after oral administration and is unaffected by the presence of food. Delavirdine is extensively metabolized, and very little is excreted as the parent compound. Fecal and urinary excretion each account for approximately half the elimination. Delavirdine is an inhibitor of CYP450–mediated drug metabolism, including that of protease inhibitors. Fluoxetine and ketoconazole increase plasma levels of delavirdine, whereas phenytoin, phenobarbital, and carbamazepine result in substantial decreases in plasma levels of delavirdine. Rash is the most common side effect of delavirdine.Delaviridine increases plasma levels of several benzodiazepines, nifedipine, protease inhibitors, quinidine, and warfarin. Delavirdine causes skin rash in up to 20% of patients, and the drug should be avoided in pregnancy because it is teratogenic in animals.Conversely, the blood levels of delavirdine are increased by azole antifungals and macrolide antibiotics.