Lamivudine

Lamivudine is approved for treatment of HIV in combination with AZT, but it should not be used with other cytosine analogs due to antagonism. Lamivudine terminates the synthesis of the proviral DNA chain, and it inhibits the reverse transcriptase of both HIV and HBV. However, it does not affect mitochondrial DNA synthesis or bone marrow precursor cells. It has good bioavailability on oral administration, depends on the kidney for excretion, and is well tolerated.Lamivudine is 80% bioavailable insomnia fatigue gi