Interferon toxicity

Toxic effects of IFN-α include GI irritation, a flu-like syndrome, neutropenia, profound fatigue and myalgia, alopecia, reversible hearing loss, thyroid dysfunction, mental confusion, and severe depression. Contraindications include pregnancy.fever cgill fatigue weight loss somnolence Interferon interferes with hepatic drug metabolism, and toxic accumulations of theophylline have been reported.Interferon may also potentiate the myelosuppression caused by other bone marrow–depressing agents such as zidovudine.