Rifapentine

It has activity comparable to that of rifampin but has a longer half-life than rifampin and rifabutin, which permits weekly dosing. However, for the intensive phase(initial 2 months) of the short-course therapy for tuberculosis, rifapentine is given twice weekly. In the subsequent phase, rifapentine is dosed once per week for 4 months. To avoid resistance issues, rifapentine should not be used alone but, rather, be included in a three to four-drug regimen.