Pregunta:
It was determined that 95% of an oral 80-mg dose of verapamil was absorbed in a 70-kg test subject. However, because of extensive biotransformation during its first pass through the portal circulation, the bioavailability of verapamil was only 25%. Assuming a liver blood flow of 1500 mL/min, the hepatic clearance of verapamil in this situation was
Autor: Jearrie Jean SumagangRespuesta:
1425 mL/min
2.25 / 5 (4 calificaciones)
1 answer(s) in total