How is passive cancer immunotherapy w/monoclonal Abs?

Mab can target : — Tumor Ag on hematological tumors — Tumor Ag on solid tumors — Receptors of immune cells infiltrating a tumor — Blood vessels irrigating a tumor Objective: Define the tumor surface-ome for a more comprehensive approach Applications: — First line treatment — Combined therapy, mainly in resistant tumors Large expansion over the last 15-20 yrs