What is characterstic of TIVHS Tuberculous granuloma?

The characteristic histologic appearance of the macrophage–T-cell infiltrate is a granuloma. ➢ This type of infiltrate in the tissue is called granulomatous inflammation ➢ One of the main features of the immune response to M. Tuberculosis is the formation of an organized structure called granuloma. ➢ Following inhalation of contaminated aerosols, M. Tuberculosis moves to the lower respiratory tract where it is recognized by alveolar macrophages ➢ M. tuberculosis are engulfed by macrophages after being identified as foreign, but due to an immuno-escape mechanism peculiar to mycobacteria no degradation ➢ Thereby TB can continue to replicate within macrophages. ➢ Granulomas form when an intracellular pathogen or its constituents cannot be totally eliminated.