What are histologic findings for LCV?

➢ Skin biopsy reveals the presence of vascular and perivascular infiltration of polymorphonuclear leukocytes with formation of nuclear dust (leukocytoclasis), extravasation of erythrocytes, and fibrinoid necrosis of the vessel walls. ➢ This process is dynamic, and biopsy of a lesion performed too early or too late in the evolution of LCV may not reveal these findings ➢ Immunofluorescent staining may reveal immunoglobulins (eg, immunoglobulin G, immunoglobulin M) and complement components (eg, C3, C4) deposited on the skin basement membrane, suggesting immune complex deposition. ➢ In Henoch-Schönlein purpura, IgA-predominant deposits may be found.