What causes LCV?

➢ LCV may be secondary to medications, underlying infection, drugs; food or food additives; collagen-vascular disorders, or malignancy. Cases of LCV have been reported following COVID-19 vaccination. ➢ However, approximately half of cases are idiopathic. ➢ The most common drugs that cause LCV are antibiotics, particularly beta-lactam drugs, nonsteroidal antiinflammatory drugs, and diuretics. ➢ However, almost all drugs are potential causes. ➢ Foreign proteins such as streptokinase, those found in vaccines, and those used in monoclonal antibody therapy can be associated with a SS syndrome with LCV Infections include RT infections, HIV, HepC, bacterial endocariditis