What are tissue and organ effects of serum sickness?

➢ IC deposition occurred in a variety of tissues and organs leading to: – generalized vasculitis (rashes) – itching – joint pain (arthralgia), especially finger and toe joints – fever, as high as 104°F and usually appears before rash – lymphadenopathy (swelling of lymph nodes), particularly near the site of injection, head and neck – malaise – hypotension – splenomegaly – glomerulonephritis – proteinuria – hematuria – shock