How is progress of ICs causing TIIIHS?

➢ When the antibody response initiates, there is a huge excess of antigens compared to antibodies (Ag:Ab>>1). ➢ The ICs that are formed are small, soluble, and quickly cleared ➢ Within 1-2 weeks, as exceedingly more antibodies are produced, a point is reached when there is only slight antigen excess, and the ICs interlace and become bigger and less soluble. ➢ The small complexes that form at slight antigen excess are viewed as being highly pathogenic and tend to deposit in small blood vessel walls; in the capillaries between the endothelial cells and the basement membrane. then vasculitis, glomerulonephritis and arthritis are commonly associated conditions as a result of type III HS responses.