How is tx of cold reactive autoantibodies?

➢ In many cases, avoidance of cold environments and other triggers of hemolysis may be all that is needed to prevent symptomatic anemia. ➢ In cases associated with a lymphoproliferative disease, treatment is directed at the underlying disorder. ➢ Rituximab is commonly used, and chemotherapy regimens used to treat B-cell cancers can be effective ➢ In severe cases, plasmapheresis is an effective temporary treatment. ➢ Transfusions should be given sparingly, with the blood warmed through an on-line warmer. ➢ Splenectomy is usually of no value and immunosuppressants have only modest effectiveness