How is combination of immediate and Late phase HS?

The immediate and late phase reactions together combine to form a severe allergic response. Activation of the recruited cells leads to the release of more chemical mediators that cause tissue damage and late-phase symptoms of swelling and redness of the skin, coughing, wheezing, and nasal discharge. ➢ Continuous or repeated exposure to an allergen can result in chronic allergic inflammation. ➢ Tissue from sites of chronic allergic inflammation contains eosinophils and T cells (particularly TH2 cells) ➢ Eosinophils can release many mediators, which can cause tissue damage and thus increase inflammation. ➢ Collectively, this results in structural and functional changes to the affected tissue. ➢ When a pre sensitized individual is exposed to an allergen, it can lead to a rapid immune response that occurs almost immediately