What are mechanisms of autoimmune tissue injury and examples?

➢ Tissue damage in autoimmune diseases can occur through several mechanisms, which are analogous to three of the classical types of hypersensitivity reactions: Type II (caused by autoantibodies reactive with cell surface or matrix antigens), Type III (caused by immune complexes), and Type IV (delayed-type hypersensitivity, mediated by T cells). ➢ Autoimmune diseases differ from HS responses in that type I IgE-mediated responses do not seem to have a major role.