How is diffuse astrocytoma?

➢A diffuse fibrillary astrocytoma is a form of glioma that is lower grade and not as extensively invasive as a glioblastoma. ➢ Account for about 80% of adult gliomas ➢They are most frequent in the fourth through the sixth decade ➢ usually are found in the cerebral hemispheres. ➢ Tend to enhance brightly because of their abnormal vascularity. ➢ This astrocytoma shows increased cellularity and pleomorphism compared with normal brain, but far less than a high-grade glioma. ➢ The clinical course may be slowly progressive for years, but astrocytomas have a tendency to become more anaplastic with time as genetic alterations accumulate within the neoplastic cells, and then more rapid deterioration ensues