How is morphology of hereditary nephritis?

➢ Glomeruli in hereditary nephritis appear unremarkable until late in the course. ➢ With progression, increasing glomerulosclerosis, vascular sclerosis, tubular atrophy, and interstitial fibrosis are typical changes ➢ Under the EM, the GBM is thin and attenuated early in the course, but over time develops irregular foci of thickening or attenuation with pronounced splitting and lamination of the lamina densa, yielding a “basketweave” appearance. ➢ In contrast to Alport syndrome, diffuse and uniform thinning of the glomerular basement membranes is the only morphologic finding in thin basement membrane disease