How is morphology of RPGN?

➢ LM changes are similar although not identical in various forms of crescentic glomerulonephritis. ➢The glomeruli show : ✓Epithelial cellular proliferation outside the capillary loops (called crescents) with migration of monocytes/macrophages into Bowman’s space ✓Cellular proliferation also is seen within the capillary loops and/or in the mesangial areas in cases with immune complex-mediated pathogenesis ✓Sometimes association of a segmental capillary necrosis ✓Breaks in GBM ✓Deposition of fibrin in Bowman’s space. ➢The crescents eventually obliterate Bowman’s space and compress the glomeruli. In time, crescents may undergo scarring, and glo- merulosclerosis develops