What is MN morphology?

➢LM : diffuse thickening of the capillary wall on routine stains ➢EM : this thickening is caused in part by subepithelial deposits, which nestle against the GBM and are separated from each other by small, spikelike protrusions of GBM matrix that form in reaction to the deposits (spike and dome pattern). ➢As the disease progresses, these spikes close over the deposits, incorporating them into the GBM. ➢With further progression, glomeruli may become sclerosed. ➢Immunofluorescence microscopy shows typical granular deposits of Ig and C3 along the GBM