How is liver physiology?

Total hepatic blood flow (about 1500 mL/min; 30 mL/min per kg body weight) constitutes 25% of the cardiac output, 2/3 of the flow enters through the portal vein 1/3 through the hepatic artery. Pressure in the portal vein is normally low (10-15 cm H2O [7-11 mm Hg]). The liver derives half of its oxygen from hepatic arterial blood and half from portal venous blood Hepatic arterial flow increases or decreases reciprocally with changes in portal flow; sudden occlusion of the portal vein results in an immediate 60% rise in hepatic arterial flow. Portal venous flow does not increase with reductions in arterial flow; sudden reductions in hepatic arterial supply are not immediately met by significant increases in portal vein flow. It is for this reason that interruption of hepatic arterial flow to the right or left liver generally has little impact on hepatic function.