What are serous carcinmomas?

➢ Typically grow in small tufts and papillae with marked cytologic atypia. ➢ They can also form glands that at times create confusion with endometrioid carcinoma, however serous carcinomas exhibit much greater cytologic atypia. ➢ behave aggressively and thus are by definition high grade ➢ Immunohistochemistry often shows diffuse, strong staining for p53 in serous carcinoma a finding that correlates with the presence of TP53 mutations (mutant p53 accumulates and hence is more easily detected by staining)