How is invasive carcinoma of cervix?

➢ The most common cervical carcinomas are : squamous cell carcinomas (75%), adenocarcinomas and mixed adenosquamous carcinomas (20%) small cell neuroendocrine carcinomas (<5%). ➢ All of these types of carcinomas are associated with HPV. ➢ SqCC has a peak incidence at the age of about 45 years, some 10 to 15 years after detection of precursor SIL. ➢ Progression of SIL to invasive carcinoma is variable and unpredictable and requires HPV infection as well as mutations in tumor suppressor genes and oncogenes