How is neoplasia of the cervix?

➢ Most tumors of the cervix are of epithelial origin and are caused by oncogenic strains of HPV. ➢ During development, the columnar mucus-secreting epithelium of the endocervix is joined to the squamous epithelial covering of the exocervix at the cervical os. ➢ With the onset of puberty, the squamocolumnar junction undergoes eversion, causing the columnar epithelium to become visible on the exocervix. ➢ The exposed columnar cells, however, eventually undergo squamous metaplasia, forming a region called the transformation zone, where tumors most commonly arise