How is pathogenesis of AML?

• Since hematopoietic cells have a rapid turnover, they are more vulnerable to chromosomal damages and cytogenetic changes. •The single most prominent characteristic of the leukemic cells is a defect in maturation beyond the myeloblast / promyelocyte level in AML, and the lymphoblast level in ALL. • AML develops due to inhibition of maturation of myeloid stem cells due to mutations. • Leukemic cells accumulate in the bone marrow  suppression of normal hematopoietic stem cells Stem cells remain in marrow capable of dividing after tx