What are etiologic and pathogenetic factors for lymphoma?

• Chromosome translocations and other acquired mutations – Translocations +++ – Mutated genes often play critical roles in the development, growth, or survival – Oncoproteins created by genomic aberrations – Proto-oncogenes often activated by errors occurring during antigen receptor gene rearrangement and diversification • Inherited genetic factors; Bloom, Fanconi, Down, ataxia teleangectasia and type I NF • Viruses; HTLV-1, EBV, HHV-8 • Chronic Immune stimulation (H. pylori, celiac, HIV) • Iatrogenic factors (radiation therapy) • Smoking (AML)