What is prostate adenocarcinoma?

• Is not the result of a transformation of BPH. • Usually develops in the peripheral zone (90%), rarely in the transitional zone. • Can result in LN metastases (pelvic, then distant LN) • Bone metastases (sclerotic) +++ • Rarely liver or lung metastases. • Usually androgen dependant • Synthesis of PSA • 2 phases: – Initial phase of hormonodependance – Resistance phase: • Usually after 2 years of HT • Adaptation-selection phenomenon • NE differentiation