How is pathogenesis of PsO?

• Complex genetic disease with many enviromental factors • Hyperproliferative state resulting in thick skin and excess scale • Skin proliferation is caused by cytokines released by immune cells • Systemic treatments of psoriasis will target these cytokines and immune cells In patients with psoriasis, the immune response is uncontrolled, resulting in a chronic production of pro-inflammatory cytokines. Multiple cytokine pathways are involved