How is exocrine action of pancreas?

1-2 L/day Clear, watery, alkaline (pH 8.0-8.3) > 20 different digestive enz. Isoosmotic to plasma Principal cations : Na & K (~165 mmol/L)Principal anions : bicarb & Cl - secrete min : Cl high, bicarb low - secrete max : Cl low, bicarb high (active transport) Passive exchange of intraductal bicarb for interstitial Cl at larger pancreatic duct digestive enzymes in acinar cells released in response to CCK and cholinergic stimulation (proteolytic, lipolytic and amylase)