Buscar
Estás en modo de exploración. debe iniciar sesión para usar MEMORY

   Inicia sesión para empezar


Por supuesto:

Pharmacology

» Iniciar este curso
(Practica preguntas similares gratis)
Pregunta:

What is mechanism of action of Ezetimibe?

Autor: H K



Respuesta:

Ezetimibe selectively inhibits intestinal absorption of dietary and biliary cholesterol in the small intestine, leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood. It lowers LDL cholesterol by 17 % and TG by 6%, It increases HDL cholesterol by 1.3 % Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation (a Phase II reaction), with subsequent biliary and renal excretion


0 / 5  (0 calificaciones)

1 answer(s) in total

Autor

H K
H K