What are uses, pharmacokinetics and effects of metoprolol and esmolol?

Metoprolol: • most widely used in the treatment of cardiac arrhythmias (selective) • Compared to nonselective beta blockers, it reduces the risk of bronchospasm • It is extensively metabolized in the liver • It has CNS penetration (less than propranolol) Esmolol: • Very-short-acting β-blocker • used for IV administration in acute arrhythmias that occur during surgery or emergency situations. • It has a fast onset of action and a Short half-life • Rapidly metabolized by esterases in red blood cells Esmolol is ideal for acute episodes of arrhythmias with limited adverse effects