What are epithelial sodium channel blockers potassium sparring diuretics?

These drugs directly prevent sodium from entering the epithelial sodium (ENaC) channels, which are found in the apical membrane of the collecting tubule. Amiloride and Triamterene They are primarily used to prevent and treat hypokalemia induced by thiazides and loop diuretic The most characteristic adverse effect of the potassium-sparing diuretics is hyperkalemia