What is cocaine?

Has the ability to block the Na+/K+-activated ATPase on the cell membrane of the adrenergic neuron. It blocks the reuptake of the monoamines (norepinephrine, serotonin, and dopamine) into the presynaptic terminals. accumulates in the synaptic space, resulting in enhancement of sympathetic activity and potentiation of the actions of epinephrine and norepinephrine. the duration of action of epinephrine and norepinephrine is increased. Cocaine is a widely available and highly addictive drug. Like amphetamines, it can increase blood pressure by α-agonist actions and β-stimulatory effects In particular, the prolongation of dopaminergic effects in the brain’s pleasure system (limbic system) produces the intense euphoria that cocaine initially causes.