Pregunta:
How are the mechanisms of actions of antipsychotics of shizophrenia?
Autor: H KRespuesta:
Atypical antipsychotics block dopamine and serotonin, block dopamine in places with alot of dopamine receptors, and block serotonin and activate dopamine in places with alot of serotonin receptors (b3alli) so in limbic dopamine is low less hallucination, in frontal dopamine a3la solves negative and affective symptoms Typical (block M1, H1, a1 and D2 effects and side effects) Atypical (all receptors + 5HT2A receptors and increase dopamine ->dopamine neuron have these receptors that brake the dopamine, so when this receptors is stopped dopamine will increase giving the atypical antipsychotics Its a matter of concentration of receptors whether dopamine or serotonin is blocked Tubuloinfundibular no effect on last two pathways which are normal Non treated pt with new gen all gets resolved
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