What is GHB?

GHB is classified as a central nervous system depressant Mechanism of action: binding to GABA, in particular the GABA-B complex Use of GHB and its precursors, (GBL) and (1,4-BD) have a dose-dependent effect on glutamate and dopamine release. At low dose, stimulation of GHB receptors increases dopamine release resulting in stimulant-like effects, whilst at higher doses, binding to GABA-B receptors results in hypnotic effects and eventually coma Method of use: orally as a liquid or in a powder mixed into drinks. Effects begin within 15 minutes of ingestion and last 2-4 hours: patients with GUD typically consume GHB every 2–3 h to prevent withdrawal symptoms