How is opioid toxicity?

Associated with route of admin (HIV/hep/infection/PE) Opioid injections (sclerosed veins and puncture marks, severe sclerosis causes peripheral edema and individuals switch to injecting in veins, legs, neck, groin then start injecting subcutaneous tissue [skin popping], resulting in cellulitis, abscesses and circular appearing scars) Life expectancy (infections, overdoses, suicides [3 times higher])