What is NHL diffuse large B-cell lymphoma?

30% carry t(14;18) indicating transformed follicular lymphoma, 20-30% carry translocations involving BCL-6 gene in B cell differentiation. It is common in immunodeficiencies a result of transformation of lymphocytes due to EBV or HHV-8 infection It is diffuse replacement of lymph node parenchyma with large pleomorphic cells Usually older pts but has a wide age range including children, usually present w/rapidly enlarging mass at either a nodal or extranodal site. Symptoms if present are usually due to mass effect or tissue destruction. Very aggressive but responds to chemo w/lasting remission seen in 50% of pt